In rheumatoid arthritis (RA), B cells contribute to chronic inflammation through autoantibody production, antigen presentation, and cytokine release. While Syk inhibitors like PRT062607 effectively suppress BCR signaling and downstream functional…
Chemotherapy resistance is a major obstacle in cancer treatment, largely driven by the overexpression of drug efflux pumps belonging to the ATP-binding cassette (ABC) transporter family. Key members such as…
Glycolipid transfer protein (GLTP) is a conserved cytosolic factor implicated in the intracellular trafficking of glycosphingolipids. Its expression is tightly linked to the biosynthetic capacity of cells to produce glucosylceramide…
Comparative genomic hybridization (CGH) has emerged as a critical tool for identifying chromosomal imbalances in rare and complex malignancies such as Xp11.2 translocation renal cell carcinoma (RCC). This study analyzed…
Protein calorie malnutrition (PCM) is a prevalent and serious condition among patients with liver cirrhosis, affecting 50% to 90% of individuals and significantly increasing the risk of morbidity and mortality.…