4-Chlorouracil – C14-demethylase

Product Name: 4-Chlorouracil

Synonym: 4-Chloro-2,6-dihydroxypyrimidine; 6-Chloro-2,4-dihydroxypyrimidine; 6-Chlorouracil

CAS Number: 4270-27-3
Empirical Formula (Hill Notation): C₄H₃ClN₂O₂
Molecular Weight: 146.53
EC Number: 224-258-0
MDL Number: MFCD00014595
Linear Formula: C₄H₃ClN₂O₂
Product Type: Chemical

CAS NO: 1396257-94-5SPHK inhibitors
Assay: ≥99%
InChI Key
PKUFNWPSFCOSLU-UHFFFAOYSA-N
Application: Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity.
Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.
Packaging:
10 g in poly bottle
Symbol
GHS07
Signal word
Warning
Hazard statements
H315-H319-H335
Precautionary statements
P261-P305 + P351 + P338
Hazard Codes
Xi
Risk Statements
36/37/38
Safety Statements
26-36
RIDADR: NONH for all modes of transport
WGK Germany: 3
Purity: ≥99%
UNSPSC
41106305
PubMed ID:http://jpet.aspetjournals.org/content/96/2/193