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Lanosterol 14 α-demethylase (or CYP51A1) is a cytochrome P450 enzyme that is concerned in the conversion of lanosterol to 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol. The cytochrome P450 isoenzymes are a conserved team of proteins that serve as important players in the fat burning capacity of natural substances and the biosynthesis of critical steroids, lipids, and natural vitamins in eukaryotes. Lanosterol 14 α-demethylase is liable for an essential move in the biosynthesis of sterols. In particular, this protein catalyzes the elimination of the C-14 α-methyl group from lanosterol. This demethylation step is regarded as the preliminary checkpoint in the transformation of lanosterol to other sterols that are broadly applied inside the mobile. An NADPH-dependent P450 enzyme that performs an vital purpose in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols this kind of as lanosterol. The enzyme functions by means of the recurring hydroxylation of the 14-methyl group, ensuing in its stepwise conversion into an alcoholic beverages, an aldehyde and then a carboxylate, which is eliminated as formic acid. Sterol fourteen-demethylase is an unusual cytochrome P450 enzyme in that it is observed in a wide selection of organisms which includes animals, vegetation, funal, and protozoa.

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