Product Name: Anti-CDC16 (111-125) antibody produced in rabbit
Synonym: Anti-APC6; Anti-
Product Type: Chemical
CAS NO: 528938VEGFR inhibitors
antibody Form: IgG fraction of antiserum
application(s)
western blot: 1:500-1:2,000
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: antigen mol wt ~72 kDa
Shipped in: dry ice
species reactivity
human
Storage temp.: −20°C
Application: CDC16 (111-125) antibody is suitable for western blot at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions:
CDC16 plays a vital role in the control process of cell progression through mitosis and the G1 phase of the cell cycle as it is a major component of the APC/C, a cell cycle-regulated E3 ubiquitin ligase. APC/C is activated by phosphorylation and acts in the process of ubiquitination and subsequent degradation of target proteins followed by control of cell cycle progression.
Features and Benefits:
Antibody Bioguarantee
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General description: CDC16 is a tetratrico peptide repeat (TPR) containing proteins. It is colocalize to the centrosome at all stages of the mammalian cell cycle, and to the mitotic spindle. It is a component of the anaphase promoting complex/cyclosome (APC/C). APC/C complex is a ubiquitin ligase that control the initiation of anaphase and mitotic exit.
Immunogen:
synthetic peptide corresponding to amino acids 111-125 of human CDC16
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/93/3/261