Product Name: Anti-COPS3 (361-375) antibody produced in rabbit
Synonym: Anti-COP9 constitutive photomorphogenic homolog subunit 3; Anti-SGN3
Product Type: Chemical
CAS NO: 112559-91-8IRE1 inhibitors
antibody Form: IgG fraction of antiserum
application(s)
western blot: 1:500-1:2,000
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: antigen mol wt ~48 kDa
Shipped in: dry ice
species reactivity
human
Storage temp.: −20°C
Application: Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-COPS3 antibody produced in rabbit is suitable for western blotting at a concentration of 1:500 to 1:2000.
Biochem/physiol Actions:
COPS3 (COP9 signalosome subunit 3) is a component of COP9 signalosome complex (CSN), which is involved in various cellular and developmental processes. The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It is necessary for maintenance of cell proliferation in the mouse embryonic epiblast. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Overexpression of the COPS3 gene is associated with the tumorigenesis process in osteosarcoma.
Features and Benefits:
Antibody Bioguarantee
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General description: COPS3 (COP9 signalosome subunit 3) encodes the third subunit of an eight-subunit complex, the COP9 signalosome (CSN), and is located on chromosome 17p11.2.
Immunogen:
synthetic peptide corresponding to amino acids 361-375 of human COPS3
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/95/1/45