Product Name: Anti-CUGBP2 antibody, Mouse monoclonal
Synonym: Anti-CUG Triplet Repeat, RNA-binding protein 2; Anti-ETR3, RNA-binding protein
MDL Number: MFCD09265421
Product Type: Chemical
CAS NO: 736994-63-1GPR84 inhibitors
antibody Form: purified immunoglobulin
application(s)
immunocytochemistry: suitable
immunoprecipitation: suitable
western blot: 30-40 μg/mL using total cell extract of mouse heart
biological source
mouse
clone
HL1889 (1H2-1F12), monoclonal
Concentration: ~1.5 mg/mL
Conjugate: unconjugated
Form: buffered aqueous solution
isotype
IgG1
Mol wt: antigen mol wt ~52 kDa
Shipped in: dry ice
species reactivity
chicken, mouse, human
Storage temp.: −20°C
Antigen Background:
CUGBP2 is an RNA-binding protein that specificallybinds to CUG repeat sequences.
Application: Suitable for immunocytochemistry, immunoprecipitation and western blotting at a working concentration of 30-40 μg/mL using total cell extract of mouse heart.
Biochem/physiol Actions:
CUGBP2 is an RNA-binding protein that specifically binds to CUG repeat sequences and is responsible for the regulation of both nuclear and cytoplasmic RNA processing events such as alternative splicing, RNA editing, mRNA stability, and translation. It is mainly expressed in muscle and brain. It regulates a specific alternative slicing of exons 5 and 21 of the N-methyl-D-aspartate receptor 1 (NMDA R1) RNA in rat. It binds to U/G-rich motifs within muscle specific enhancer elements (MSEs) and activates inclusion of an alternative exon in cardiac troponin T (cTNT) pre-mRNAs. It interacts with A/U rich sequences in the 3′ UTR and inhibits translation of cycloxygenase-2 (COX-2) mRNAs.
Features and Benefits:
Antibody Bioguarantee
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Immunogen:
divergent domain of human CUGBP2 corresponding to amino acids 209-415 (accession no. NP006552).
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/95/4/460