Product Name: Anti-CXCR4 (Fusin), N-Terminal antibody produced in rabbit
MDL Number: MFCD02096161
Product Type: Chemical
CAS NO: 152811-62-6Beta-secretase inhibitors
antibody Form: IgG fraction of antiserum
application(s)
western blot: 1-2 μg/mL using human HeLa cell extract.
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: buffered aqueous solution
Shipped in: dry ice
species reactivity
human
Storage temp.: −20°C
Application: Anti-CXCR4 (Fusin), N-Terminal antibody can be used in immunoblotting and immunocytochemistry.
Biochem/physiol Actions:
CXCR4 is a cell surface receptor of the chemokine CXCL12 (SDF-1) and is involved in metastasis, hematopoiesis and immune responses. It acts with CD4 to facilitate the entry of HIV into target cells. CXCR4 has important roles in tumor initiation, proliferation, invasion and metastasis of breast cancer cells.
General description: Chemokine receptor CXCR-4 also refers as fusin or LESTR is a protein that belongs to G-protein coupled receptor 1 family. It is an essential cofactor for T cell-tropic HIV viruses into CD4+ cells. N-Terminal domain and second extracellular loop of the protein act as a HIV binding sites. Anti-CXCR4 (Fusin), N-Terminal antibody can be used to block HIV-1 and HIV-2 fusion and infection of human target cells. It can also be used in immunoprecipitation. Rabbit anti- CXCR4 (Fusin), N-Terminal antibody reacts specifically with human CXCR4.
Immunogen:
synthetic peptide corresponding to amino acids 1-14 of the N-terminal of human CXCR4.
Other Notes:
The antigen (receptor) is also termed fusin, LESTER and HUMSTR.
Physical Form: Solution in phosphate buffered saline, containing 0.02% sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: nwg
Storage Temp.: −20°C
UNSPSC
51111800
PubMed ID:http://jpet.aspetjournals.org/content/93/1/40