Product Name: Anti-Caspase 10 antibody produced in rabbit
MDL Number: MFCD01865513
Product Type: Chemical
CAS NO: 892546-37-1FGFR inhibitors
antibody Form: affinity isolated antibody
application(s)
microarray: suitable
western blot: 1:500 using a whole extract of Jurkat human acute T leukemia cells extract
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: antigen mol wt 59 kDa
Shipped in: dry ice
species reactivity
human
Storage temp.: −20°C
Application: Anti-Caspase 10 antibody was used in Immunohistochemistry, western blot and tissue microarray to study the proteomics for esophageal cancer.
Biochem/physiol Actions:
Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis which is induced by a variety of inducers such as TNF-α and Anti-Fas antibody. It is a large- prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoForms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. It plays a key role in the NF-κB pathway and NF-κB, a signal transduction factor, plays an important part in the carcinogenesis of esophageal cancer. Overexpression of a caspase 10 increases NF-κB activity. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature Form of caspase 10 comprises two subunits, p23/p17 (splice isoForms) and p12. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9.
General description: Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 is a apoptosis-related cysteine protein. It contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas.
Immunogen:
synthetic peptide corresponding to amino acid residues 359-372 of human caspase 10a p23/p17 with N-terminal added lysine conjugated to KLH with glutaraldehyde.
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/93/2/210