Product Name: Anti-Caspr2 antibody produced in rabbit
Synonym: Anti-
MDL Number: MFCD03791625
Product Type: Chemical
CAS NO: 88546-55-8Fungal inhibitors
antibody Form: affinity isolated antibody
application(s)
western blot: 1:1,000 using rat brain membranes
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: lyophilized powder
Mol wt: antigen mol wt 180 kDa
species reactivity
mouse, rat
Storage temp.: −20°C
Application: Anti-CASPR2 antibody has been used for immunohistochemitry and western blotting of proteins from mouse brain samples. It is also suitable for western blot analysis at a dilution of 1:1,000 by using rat brain membranes.
Biochem/physiol Actions:
CASPR2 (Contactin-associated protein-like 2) associates shaker like K+ channels in the juxtaparanodal region flanking nodes of Ranvier. It is expressed in different and distinct regions of the central nervous system (CNS) where it may plays an important role in cell recognition. CASPR and CASPR2 may interact with the actin-based cytoskeleton through cytoskeleton-associated protein 4.1B. CASPR2 is crucial for synapse Formation and outgrowth of axon and dendrite. CASPR2 Forms a complex with G-protein-coupled receptor 37 (GPR37) and multiple PDZ domain protein 1 (MUPP1). Disruption of the complex is linked with autism spectrum disorder (ASD). Genetic variations in CASPR2 are also associated with intellectual disability, epilepsy, schizophrenia and language disorders. It also regulates diet-induced obesity.
Features and Benefits:
Antibody Bioguarantee
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General description: CASPR2 (Contactin-associated protein-like 2) belongs to CASPR family and neurexin superfamily.
Immunogen:
peptide corresponding to amino acids residues 1315-1331 of human Caspr2. This sequence is identical in the mouse protein.
Physical Form: Lyophilized from 0.3 mg/ml in phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and 0.025% sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/94/2/209