Product Name: Anti-Caveolin-2 antibody produced in rabbit
MDL Number: MFCD01633098
Product Type: Chemical
CAS NO: 1020399-49-8Glucokinase inhibitors
antibody Form: affinity isolated antibody
application(s)
indirect immunofluorescence: suitable
biological source
rabbit
clone
polyclonal
Concentration: ~1 mg/mL
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: antigen mol wt ~20 kDa
Shipped in: dry ice
species reactivity
canine, rat, human (predicted), pig (predicted), mouse
Storage temp.: −20°C
Application: Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-Caveolin-2 antibody produced in rabbit is suitable for immunoblotting at a working concentration of 1-2 μg/mL using a whole extract of mouse 3T3-l1 adipocytes or using a whole extract of rat kidney NRK cell line. It was used for the detection of caveolin-2, a marker proteins of lipid rafts, by immunoblotting in a study. It was used as a primary antibody in western blotting to investigate the role of caveolin in the remodelling of the basolateral plasma membrane of uterine epithelial cells during early pregnancy in rat.
Biochem/physiol Actions:
Caveolin-2 colocalizes and Forms a hetero-oligomeric complex with caveolin-1 in vivo. Caveolins family members function as scaffolding proteins to organize and concentrate specific lipids such as cholesterol and glycosylphosphatidylinosi
Features and Benefits:
Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perForm in your application, we will issue a full credit or replacement antibody. Learn more.
General description: Caveolin-2 is an isoForm of caveolin, an integral transmembrane protein of the caveolae membranes. It has a molar mass of 20-22 kDa and is a major coat protein found in caveolae of most cell types. It exists as two isoForms α and β due to alternative splicing of the respective mRNAs. Caveolin-2α corresponds to the full-length protein (20 kDa, 162 amino acids), whereas caveolin-2β isoForm lacks a 13 amino acid sequence at its N-terminus.
Immunogen:
synthetic peptide corresponding to amino acids 1-20 located at the N-terminus of mouse caveolin-2, conjugated to KLH. This sequece is identical in rat caveolin-2, highly conserved (90% identity) in human, dog, and pig caveolin-2, and is not found in caveolin-1 and caveolin-3.
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/97/2/140