Product Name: Anti-CtBP1, N-terminal antibody produced in rabbit
Synonym: Anti-
MDL Number: MFCD07784627
Product Type: Chemical
CAS NO: TSH Receptor inhibitors
antibody Form: IgG fraction of antiserum
application(s)
immunoprecipitation: 5-10 μL using lysates of K562 cell line
microarray: suitable
western blot: 1:250-1:500 using mouse brain lysates
western blot: 1:500-1:1,000 using K562 cells
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: antigen mol wt 48 kDa
Shipped in: dry ice
species reactivity
human, mouse
Storage temp.: −20°C
Application: Anti-CtBP1, N-terminal antibody produced in rabbit is suitable for immunoprecipitation and immunoblotting at a working dilution of 1:500-1:1000 using cell lysates of the K562 cell line and 1:250-1:500 using mouse brain lysates.
Biochem/physiol Actions:
Apart from E1A protein, CtBP1 interacts with a wide variety of cellular factors such as DNA-binding transcription factors that participate in several developmental biological pathways and processes by binding to the carboxy terminal. It also interacts with polycomb group proteins and thus a component of the chromatin remodeling machinery and transcriptional repression. Pnn/DRS, a phosphoprotein involved in the regulation of cell adhesion and modulation of the activity of multiple tumor supressor genes, interacts with CtBP1 and may modulate repression of E-cadherin transcription. CtBP1 associates with SMAD6 and represses BMP signaling of the TGF-β pathway in the nucleus. It acts as transcriptional coregulator in histone acetyltransferase or histone deacetylase (HDAC)-dependent and independent manner.
Features and Benefits:
Antibody Bioguarantee
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Immunogen:
synthetic peptide corresponding amino acids 2-18 of human CtBP1. This sequence is conserved in mouse and does not cross-react with CtBP2.
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/96/2/114