Product Name: CHIC-35
Synonym: (6S)
CAS Number: 848193-72-6
Empirical Formula (Hill Notation): C14H15ClN2O
Molecular Weight: 262.73
MDL Number: MFCD11045286
Linear Formula: C14H15ClN2O
Product Type: Chemical
CAS NO: 55488-86-3HCV inhibitors
Assay: ≥97% (chiral, HPLC)
Form: solid
InChI Key
ABIVOOWWGYJNLV-JTQLQIEISA
solubility
DMSO: >10 mg/mL
H2O: <2 mg/mL
Storage temp.: 2-8°C
Biochem/physiol Actions:
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.
Features and Benefits:
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Symbol
GHS06
Signal word
Danger
Hazard statements
H301-H315-H319-H335
Precautionary statements
P261-P301 + P310-P305 + P351 + P338
Hazard Codes
Xn
Risk Statements
36/37/38
Safety Statements
26
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Purity: ≥97% (chiral, HPLC)
Storage Temp.: 2-8°C
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/94/2/85