Cardamonin

Product Name: Cardamonin

Synonym: (2E)–1-(2,4-Dihydroxy-6-methoxyphenyl)–3-phenyl-2-propen-1-one; (8CI); Alpinetin chalcone; (E)-2′,4′-Dihydroxy-6′-methoxy-chalcone

CAS Number: 19309-14-9
Empirical Formula (Hill Notation): C₁₆ H₁₄ O₄
Molecular Weight: 270.28
MDL Number: MFCD00238554
Linear Formula: C₁₆ H₁₄ O₄
Product Type: Chemical

CAS NO: 58-89-9PDK-1 inhibitors
Assay: ≥98% (HPLC)
color
yellow
Form: powder
InChI Key
NYSZJNUIVUBQMM-BQYQJAHWSA-N
solubility
DMSO: ≥20 mg/mL
Storage temp.: room temp
Biochem/physiol Actions:
Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.
Other Notes:
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C8249.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Hazard Codes
N
Risk Statements
50/53
Safety Statements
61
RIDADR: UN 3077 9 / PGIII
Purity: ≥98% (HPLC)
Storage Temp.: room temp
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/93/2/142