Product Name: Cathepsin D from human liver
CAS Number: 9025-26-7
MDL Number: MFCD00130749
Product Type: Chemical
CAS NO: 11021-13-9Steroids inhibitors
color
white
Form: lyophilized powder
Mol wt: mol wt ~45 kDa
Storage temp.: −20°C
Biochem/physiol Actions:
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Other Notes:
Contains α, β and γ isoenzymes as observed by isoelectric-focusing.
Physical Form: Powder containing sodium phosphate buffer salt.
Unit Definition:
One unit will produce an increase in A280 of 1.0 in 30 min at pH 3.3 at 37°C measured as TCA-soluble products using acid-denatured hemoglobin as substrate (1 cm light path).
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
Enzyme Commission (EC) Number
3.4.23.5(BRENDA|IUBMB)
UNSPSC
12352204
PubMed ID:http://jpet.aspetjournals.org/content/94/2/136