Product Name: Chetomin
Synonym: Chaetomin; NSC 289491
CAS Number: 1403-36-7
Empirical Formula (Hill Notation): C31H30N6O6S4
Molecular Weight: 710.87
Linear Formula: C31H30N6O6S4
Product Type: Chemical
CAS NO: 1246815-96-2MEK inhibitors
Assay: ≥98% (HPLC)
biological source
from Chaetomium cochliodes
solubility
acetone: soluble
DMSO: soluble
ethyl acetate: soluble
Storage temp.: −20°C
Biochem/physiol Actions:
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin disrupts the hypoxia-inducible factor (HIF) pathway, blockomg the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth; hypoxia can also promote resistance to radiotherapeutics. By both of these mechanisms, chetomin shows promise as a lead compound in antitumor research. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
Biochem/physiol Actions:
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
Symbol
GHS06
Signal word
Danger
Hazard statements
H301
Precautionary statements
P301 + P310
Hazard Codes
T
Risk Statements
25
Safety Statements
45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Purity: ≥98% (HPLC)
Storage Temp.: −20°C
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/96/3/258