Product Name: Cyclin-Dependent Kinase 5 human
MDL Number: MFCD06201997
Product Type: Chemical
CAS NO: 73590-85-9HBV inhibitors
packaging
vial of 300 units
Recombinant: expressed in E. coli BL21
Shipped in: dry ice
Storage temp.: −70°C
Application: Human cyclin-dependent kinase 5 has been used in a study to determine its 3’ untranslated region subunit 1 contains regulatory elements that affect transcript stability.
Biochem/physiol Actions:
CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.
Physical Form: Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA
Unit Definition:
One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 °C at pH 7.4.
RIDADR: NONH for all modes of transport
WGK Germany: 2
Storage Temp.: −70°C
UNSPSC
12352204
PubMed ID:http://jpet.aspetjournals.org/content/94/2/215