L-Carnosine

Product Name: L-Carnosine

Synonym: β-Alanyl-L-histidine

CAS Number: 305-84-0
Empirical Formula (Hill Notation): C₉H₁₄N₄O₃
Molecular Weight: 226.23
Beilstein Registry Number: 87671
EC Number: 206-169-9
MDL Number: MFCD00005207
Linear Formula: C₉H₁₄N₄O₃
Product Type: Chemical

CAS NO: 27975-19-5p38 MAPK inhibitors
Assay: ~99%
Form: crystalline
InChI Key
CQOVPNPJLQNMDC-ZETCQYMHSA-N
mp
253 °C (dec.)(lit.)
Storage temp.: −20°C
Amino Acid Sequence:
Ala-His
Biochem/physiol Actions:
L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, Formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the Formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.
Biochem/physiol Actions:
Dipeptide with potent antioxidant and antiglycation activity; blocks nonenzymatic glycosylation and protein cross-linking induced by reactive aldehydes.
Other Notes:
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C9625.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Packaging:
10 mg in poly bottle
Packaging:
5, 25, 100 g in poly bottle
RIDADR: NONH for all modes of transport
WGK Germany: 2
Purity: ~99%
mp
253 °C (dec.)(lit.)
Storage Temp.: −20°C
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/96/3/276