Product Name: Monoclonal Anti-COX II antibody produced in mouse
Synonym: Anti-Cyclooxygenase II
MDL Number: MFCD00217771
Product Type: Chemical
CAS NO: 1313725-88-0GPR109A inhibitors
antibody Form: purified immunoglobulin
application(s)
flow cytometry: 1 μg/test
indirect ELISA: suitable
microarray: suitable
western blot: suitable
biological source
mouse
clone
AS66, monoclonal
Conjugate: unconjugated
Form: buffered aqueous solution
isotype
IgG1
Shipped in: dry ice
species reactivity
human
Storage temp.: −20°C
Application: Monoclonal Anti-COX II antibody produced in mouse is suitable for immunoblotting at a working concentration of 1 to 5 μg/mL, indirect ELISA, microarray and flow cytometry at 1 μg/test.
Biochem/physiol Actions:
COX-II is a target of NSAID (non-steroidal anti-inflammatory drugs) such as aspirin. It is induced in migratory cells responding to pro-inflammatory stimuli and is an important mediator of inflammation. The prostaglandins produced by COX-II are responsible for the pain and swelling from inflammation. As this enzyme is involved in the production of inflammatory agents, it is the target of intense research and drug discovery activities. COX-II is expressed in new angiogenic endothelial cells, synoviocytes from rheumatoid arthritis patients. It is also markedly expressed in 85% to 90% of human colorectal adenocarcinomas.
Features and Benefits:
Antibody Bioguarantee
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General description: COX-II is an isoForm of COX enzyme with 604 amino acid residues that catalyzes the conversion of arachinodate to prostaglandin H2.
Immunogen:
recombinant full length human COX II, 604 amino acids.
Physical Form: Solution in phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.
RIDADR: NONH for all modes of transport
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/95/4/438