Have shown that reductions in central mAChR systems were present not only in Alzheimer’s-type dementia [10,11] but also in Huntington’s disease [12?4], Parkinson’s disease [15], and schizophrenia [16?8]. Five subtypes of mAChR, M1?, have been identified by molecular cloning [19], and the M1 receptor has a significant role in cognitive function [3,20]. These results suggest …
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