Name :
Recombinant Cynomolgus FGF1 Protein
Biological Activity :
Background :
aFGF, also known as FGF1 and HBGF-1, is a member of the fibroblast growth factor family. The biological activity of aFGF protein is exerted through binding to four high affinity cell surface receptors (FGFR1–4), which results in receptor dimerization and transphosphorylation in the tyrosine kinase domain. aFGF protein shows a wide range of endocrine-like activities. As a multiple function growth factor, this protein is involved in embryo development and tissue repair. Additionally, this protein is considered to function in several important physiological and pathological processes, such as embryonic development, morphogenesis, angiogenesis, wound healing and atheromatosis, carcinogenesis, development, and invasion of cancer. References
Biological Activity :
Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts.The ED50 for this effect is typically 0.1-0.4 ng/mL.
Expression Host :
Cynomolgus
Source :
E. coli
Tag :
Protein Accession No. :
NCBI Gene ID :
Synonyms :
Synonyms :
fibroblast growth factor 1 (acidic)
Amino Acid Sequence :
Molecular Weight :
The recombinant cyno FGF1 consists of 141 amino acids and has a calculated molecular mass of 16 kDa. It migrates as an 16 KDa band in SDS-PAGE under reducing conditions.
Purity :
> 95 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
Please contact us for more information.
Protein Construction :
A DNA sequence encoding the Cynomolgus FGF1 (Phe16-Asp155) was expressed and purified with an initial Met.
Buffer Solution :
Supplied as sterile PBS, pH 7.4, 20% glycerol.Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
Liquid. It is shipped out with blue ice.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
References & Citations :
Jaye M., et al.,(1986), Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. Science 233:541-545.Mergia A., et al., (1989), Structural analysis of the gene for human acidic fibroblast growth factor.Biochem. Biophys. Res. Commun. 164:1121-1129.Wang W.P., et al.,(1989), Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.Mol. Cell. Biol. 9:2387-2395.
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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