Name :
Recombinant Human UBA6 Protein (GST Tag)
Biological Activity :
Background :
UBA6 (Ubiquitin Like Modifier Activating Enzyme 6) is a Protein Coding gene. The UBA6 gene, located on 4q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. Uba6 is a homolog of the ubiquitin-activating enzyme, Uba1, and activates two ubiquitin-like proteins (UBLs), ubiquitin and FAT10. UBA6 is an alternative enzyme for ubiquitin activation in vertebrates that plays a pivotal role in early mouse development. UBA6 is widely expressed in the lymph node, appendix, and other tissues. Diseases associated with UBA6 include Ichthyosis, Congenital, Autosomal Recessive 4A, and Johanson-Blizzard Syndrome. Among its related pathways are the Metabolism of proteins and the Innate Immune System.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
Baculovirus-Insect Cells
Tag :
Protein Accession No. :
A0AVT1
NCBI Gene ID :
Synonyms :
Synonyms :
ubiquitin-like modifier activating enzyme 6
Amino Acid Sequence :
Molecular Weight :
The recombinant Human UBA6 consists of 1271 amino acids and predicts a molecular mass of 143.56 kDa. It migrates as an approximately 117.02 kDa band in SDS-PAGE under reducing conditions.
Purity :
≥ 80 % as determined by SDS-PAGE.
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg protein as determined by the LAL method.
Protein Construction :
A DNA sequence encoding the Human UBA6 (A0AVT1) (Met1-Asp1052) was expressed with an N-terminal GST tag.
Buffer Solution :
Lyophilized from sterile 20mM Tirs, 500mM Nacl, 10%glycerol, 0.5mM PMSF, 0.5mM TCEP, 2mM GSH, pH 7.5.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
E1-L2 Protein, Human; MOP-4 Protein, Human; UBE1L2 Protein, Human UBA6 背景信息 UBA6 (Ubiquitin Like Modifier Activating Enzyme 6) is a Protein Coding gene. The UBA6 gene, located on 4q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. Uba6 is a homolog of the ubiquitin-activating enzyme, Uba1, and activates two ubiquitin-like proteins (UBLs), ubiquitin and FAT10. UBA6 is an alternative enzyme for ubiquitin activation in vertebrates that plays a pivotal role in early mouse development. UBA6 is widely expressed in the lymph node, appendix, and other tissues. Diseases associated with UBA6 include Ichthyosis, Congenital, Autosomal Recessive 4A, and Johanson-Blizzard Syndrome. Among its related pathways are the Metabolism of proteins and the Innate Immune System.
References & Citations :
Kim MJ, et al. (2019) Early-stage paired housing improves social interaction in neuronal uba6-deficient mice. Biochem Biophys Res Commun 514 (2): 545-549.Gavin JM, et al. (2012) Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, fat10, by ubiquitin-like modifier activating enzyme 6, uba6. J Biol Chem 287 (19): 15512-15522.Chen Z, et al. (2020) Down-regulation of uba6 exacerbates brain injury by inhibiting the activation of notch signaling pathway to promote cerebral cell apoptosis in rat acute cerebral infarction model. Mol Cell Probes 53 101612.
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