Cucurbitacin B hydrate

Product Name: Cucurbitacin B hydrate

Synonym: (2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione

CAS Number: 6199-67-3 (anhydrous)
Empirical Formula (Hill Notation): C₃₂H₄₆O₈ · xH₂O
Molecular Weight: 558.70 (anhydrous basis)
MDL Number: MFCD07778083
Linear Formula: C₃₂H₄₆O₈ · xH₂O
Product Type: Chemical

CAS NO: 1314118-92-7Others inhibitors
Assay: ≥97% (HPLC)
color
white to beige
Form: powder
InChI Key
IXQKXEUSCPEQRD-DKRGWESNSA-N
solubility
DMSO: soluble10 mg/mL, clear
Storage temp.: 2-8°C
Biochem/physiol Actions:
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.
Features and Benefits:
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Features and Benefits:
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Symbol
GHS06
Signal word
Danger
Hazard statements
H300
Precautionary statements
P264-P301 + P310
Hazard Codes
T
Risk Statements
25
Safety Statements
45
RIDADR: UN 2811 6.1 / PGI
WGK Germany: 3
Purity: ≥97% (HPLC)
Storage Temp.: 2-8°C
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/93/3/420