COG 133 trifluoroacetate salt

Product Name: COG 133 trifluoroacetate salt

Synonym: Ac- LRVRLASHLRKLRKRLL-NH2; Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2; COG133; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide; apoE(133-149)

CAS Number: 514200-66-9 (free base)
Empirical Formula (Hill Notation): C₉₇H₁₈₁N₃₇O₁₉ · xC₂HF₃O₂
Molecular Weight: 2169.71 (free base basis)
MDL Number: MFCD18432706
Linear Formula: C₉₇H₁₈₁N₃₇O₁₉ · xC₂HF₃O₂
Product Type: Chemical

CAS NO: 56632-39-4Wnt/Hedgehog/Notch_Compound_Library inhibitors
Assay: ≥95% (HPLC)
color
white
Form: lyophilized
InChI Key
SIAUOBGYBRMVPH-BGJGLIJFSA-N
solubility
H2O: >1 mg/mL
Storage temp.: −20°C
Biochem/physiol Actions:
COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low-density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Purity: ≥95% (HPLC)
Storage Temp.: −20°C
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/94/1/60