Cinoxacin

Product Name: Cinoxacin

Synonym: 1-Ethyl-1,4-dihydro-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid

CAS Number: 28657-80-9
Empirical Formula (Hill Notation): C₁₂H₁₀N₂O₅
Molecular Weight: 262.22
EC Number: 249-133-8
MDL Number: MFCD00056776
Linear Formula: C₁₂H₁₀N₂O₅
Product Type: Chemical

CAS NO: 1516896-09-5Protease_Inhibitor_Cocktail inhibitors
antibiotic activity spectrum
Gram-negative bacteria
Form: solid
InChI Key
VDUWPHTZYNWKRN-UHFFFAOYSA-N
Mode of action
DNA synthesis | interferes

enzyme | inhibits
solubility
1 M NaOH: soluble50 mg/mL
Application: Cinoxacin was used to study the rat renal organic anion transporter 1 (OAT1). It is used to study fluoroquinolone-resistant Streptococcus pyogenes.
Biochem/physiol Actions:
Cinoxacin is a synthetic antimicrobial agent that interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding. The mechanism of action of cinoxacin is comparable to nalidixic acid. Cinoxacin is effective against Gram-negative bacteria and is often used to treat urinary tract infections caused by E. coli, Proteus mirabilis, Proteus vulgaris and Klebsiella sp.
Other Notes:
Keep container tightly closed in a dry and well-ventilated place.
Other Notes:
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C8645.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
RIDADR: NONH for all modes of transport
WGK Germany: 2
RTECS
JI4640000
UNSPSC
51101500
PubMed ID:http://jpet.aspetjournals.org/content/94/1/68