Product Name: Monoclonal Anti-COX I antibody produced in mouse
Synonym: Anti-Cyclooxygenase I
MDL Number: MFCD00217772
Product Type: Chemical
CAS NO: 1448346-38-0Adrenergic Receptor inhibitors
antibody Form: purified immunoglobulin
application(s)
indirect ELISA: suitable
western blot: suitable
biological source
mouse
clone
AS70, monoclonal
Concentration: 1 mg/mL
Conjugate: unconjugated
Form: buffered aqueous solution
isotype
IgG1
Shipped in: dry ice
species reactivity
human
Storage temp.: −20°C
Application: Monoclonal Anti-COX I antibody produced in mouse is suitable for ELISA and western blotting. It was used to detect mitochondrial cytochrome c oxidase protein markerin homogenate and lipid droplet fractions isolated from L-cells by western blot analysis.
Biochem/physiol Actions:
COX-I, an isoForm of COX enzyme with 599 amino acid residues, catalyzes the conversion of arachinodate to prostaglandin H2. It is expressed mainly in the gut for the production of prostaglandins, which inhibit gastric secretion. It is involved in the regulation of homeostatic functions throughout the body, such as vascular hemostasis, renal blood flow, and maintenance of glomerular function. It is a target of NSAID (non-steroidal anti-inflammatory drugs) such as aspirin. COX-I can be induced by IL-β and other cytokines in monocytes, macrophages, and other cells as part of the inflammatory response.
Features and Benefits:
Antibody Bioguarantee
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Immunogen:
recombinant full length human COX I, 599 amino acids.
Physical Form: Solution in phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.
WGK Germany: –
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/95/3/312