Product Name: Anti-Chloride Channel-2 (CLC-2, Clcn2) antibody produced in rabbit
MDL Number: MFCD02096079
Product Type: Chemical
CAS NO: 1188266-14-9RGS Protein inhibitors
antibody Form: affinity isolated antibody
application(s)
western blot (chemiluminescent): 1:200-1:400 using rat membranes and ECL
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: lyophilized powder
species reactivity
rat
Storage temp.: −20°C
Application: Anti-Chloride Channel-2 antibody produced in rabbit is suitable for western blot (chemiluminescent) at a working dilution of 1:200-1:400 using rat membranes and ECL.
Biochem/physiol Actions:
The encoded protein, voltage-gated chloride channel, is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Autosomal-recessive mutations ion this gene cause a leukoencephalopathy that affects brain ion and water homoeostasis. It is characterized by intramyelinic oedema. It is involved in maintaining the volume of trabecular meshwork cells by adjusting the outflow of aqueous solutions and for maintaining the fluid balance. It may be a potential target for the treatment of primary open angle glaucoma.
Features and Benefits:
Antibody Bioguarantee
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Immunogen:
synthetic peptide corresponding to amino acids 888-906 of the rat chloride channel-2 (CLC-2).
Physical Form: Lyophilized at ~0.6 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide
WGK Germany: 2
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/96/1/56