Product Name: Monoclonal Anti-CD152 antibody produced in mouse
Synonym: Anti-CTLA-4
MDL Number: MFCD01864928
Product Type: Chemical
CAS NO: 1449236-96-7Enolase inhibitors
antibody Form: purified immunoglobulin
application(s)
neutralization: suitable
western blot: suitable
biological source
mouse
clone
AS32, monoclonal
Concentration: ~1 mg/mL
Conjugate: unconjugated
Form: buffered aqueous solution
isotype
IgG1
Shipped in: wet ice
species reactivity
human
Storage temp.: 2-8°C
Antigen Background:
CD152, a cell surface glycoprotein, is one of two ligands (the other is CD28) for CD80 (B7-1) and CD86 (B7-2). This interaction appears to function as a negative regulator to T cell activation. CD152 is transiently expressed on activated T cells.
Application: Monoclonal Anti-CD152 antibody produced in mouse is suitable for western blotting and for neutralization studies, where this antibody has been shown to block the interaction of soluble human CD152 with human CD80.
Biochem/physiol Actions:
CD152 and CD28 together with their ligands constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. CD152 acts as a co-stimulatory molecule in eliciting T cell help during antigen presentation and functions as a negative regulator of T cell activation.
Features and Benefits:
Antibody Bioguarantee
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General description: CD152 is structurally similar to CD28 and is a member of the immunoglobin (Ig) gene superfamily. The gene encoding human CD152 is present on chromosone 2. It is composed of a single Ig V-like extracellular domain, a transmembrnne domain, and an intracellular domain. It is mainly expressed by cytotoxic T lymphocytes and the level of expression is activation-dependent.
Immunogen:
recombinant extracellular domain of human CD152.
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.
Preparation Note: Prepared from tissue culture supernatant, purified using protein G.
RIDADR: NONH for all modes of transport
WGK Germany: 2
Storage Temp.: 2-8°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/97/1/i