Product Name :
Rabbit anti-SIRT3 Polyclonal Antibody(C-term)
Synonym :
NAD-dependent protein deacetylase sirtuin-3; mitochondrial; hSIRT3; 351-; Regulatory protein SIR2 homolog 3; SIR2-like protein 3; SIRT3; SIR2L3
Host :
Rabbit
Species Reactivity:
Human, Mouse
Specificity :
This SIRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the C-terminal region of human SIRT3.
Predicted Reactivity:
Applications :
WB~~1:1000IHC-P~~1:50~100
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Cancer;Cardiovascular;Cell Biology;Metabolism
Background :
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
UniProt :
Q9NTG7
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Purified Rabbit Polyclonal Antibody (Pab) |Synonym NAD-dependent protein deacetylase sirtuin-3; mitochondrial; hSIRT3; 351-; Regulatory protein SIR2 homolog 3; SIR2-like protein 3; SIRT3; SIR2L3 |Host Rabbit |Specificity This SIRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the C-terminal region of human SIRT3. |Species Reactivity Human, Mouse |Applications WB~~1:1000IHC-P~~1:50~100 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |Research areas Cancer;Cardiovascular;Cell Biology;Metabolism |Target |Background NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. |Cellular localization Mitochondrion matrix |UniProt Q9NTG7 |References |References Hirschey, M.D., et al. Nature 464(7285):121-125(2010) Pillai, V.B., et al. J. Biol. Chem. 285(5):3133-3144(2010) Kim, H.S., et al. Cancer Cell 17(1):41-52(2010) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-SIRT3 Polyclonal Antibody(C-term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
2110448-99-0 medchemexpress 1456699-27-6 supplier PMID:30844179 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com