Name :
Recombinant Human Thioredoxin reductase 1/TRXR1 Protein (aa 161-647, His Tag)
Biological Activity :
Background :
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.
Biological Activity :
Testing in progress
Expression Host :
Human
Source :
E. coli
Tag :
Protein Accession No. :
Q16881-1
NCBI Gene ID :
Synonyms :
Synonyms :
thioredoxin reductase 1
Amino Acid Sequence :
Molecular Weight :
The recombinant human TXNRD1 consisting of 498 amino acids and has a calculated molecular mass of 55 kDa. It migrates as an 60 kDa band in SDS-PAGE under reducing conditions as predicted.
Purity :
> 90 % as determined by SDS-PAGE
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
Please contact us for more information.
Protein Construction :
A DNA sequence encoding the human TXNRD1 isoform 1 (Q16881-1) (Tyr 161-Cys 647) was expressed, with a polyhistide tag at the N-terminus.
Buffer Solution :
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
GRIM-12 Protein, Human; TR Protein, Human; TR1 Protein, Human; TRXR1 Protein, Human; TXNR Protein, Human Thioredoxin reductase 1/TRXR1 背景信息 Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.
References & Citations :
Gasdaska P.Y., et al., 1995, FEBS Lett. 373:5-9. Rundloef A.-K., et al., 2004, Free Radic. Biol. Med. 36:641-656. Rikova K., et al., 2007, Cell 131:1190-1203. Fritz-Wolf K., et al., 2007, J. Mol. Biol. 370:116-127. Choudhary C., et al., 2009, Science 325:834-840.
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