7159. 10. Chen LJ, Su XW, Qiu PX, Huang YJ, Yan GM Thermal preconditioning protected cerebellar granule neurons of rats by modulating HSP70 expression. Acta Pharmacol Sin 25: 458461. 11. Cheng L, Smith DJ, Anderson RL, Nagley P Human neuroblastoma SHSY5Y cells show increased resistance to hyperthermic stress after differentiation, associated with elevated levels of Hsp72. Int J Hyperthermia 27: 415426. 12. Steel R, Doherty JP, Buzzard K, Clemons N, Hawkins CJ, et al. Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1. J Biol Chem 279: 5149051499. 13. Stankiewicz AR, Lachapelle G, Foo CP, Radicioni SM, Mosser DD Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. J Biol Chem 280: 3872938739. 14. Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, et al. Heatshock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2: 469475. 15. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol 2: 476483. 16. Mosser DD, Martin LH Induced thermotolerance to apoptosis in a human T lymphocyte cell line. J Cell Physiol 151: 561570. 17. Poe BS, O’Neill KL Inhibition of protein synthesis sensitizes thermotolerant cells to heat shock induced apoptosis. Apoptosis 2: 510517. 18. Harmon BV, Corder AM, Collins RJ, Gobe GC, Allen J, et al. Cell death induced in a murine LGX818 mastocytoma by 4247 degrees C heating in vitro: 
evidence that the form of death changes from apoptosis to necrosis above a critical heat load. Int J Radiat Biol 58: 845858. 19. Oh JE, Karlmark KR, Shin JH, Pollak A, Freilinger A, et al. Differentiation of neuroblastoma cell line N1E-115 involves several signaling cascades. Neurochem Res 30: 333348. 20. Bertrand R, Solary E, O’Connor P, Kohn KW, Pommier Y Induction of a common pathway of apoptosis by staurosporine. Exp Cell Res 211: 314321. 21. Lim ML, Chen B, Beart PM, Nagley P Relative timing of redistribution of cytochrome c and Smac/DIABLO from mitochondria during apoptosis assessed by double immunocytochemistry on mammalian cells. Exp Cell Res 312: 11741184. 22. Hansen TM, Smith DJ, Nagley P Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c. Cell Death Differ 13: 11811190. 23. Bossy-Wetzel E, Newmeyer DD, Green DR Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 17: 3749. 24. Desagher S, Martinou JC Mitochondria as the central control point of apoptosis. Trends Cell Biol 10: 369377. 25. Hsu YT, Youle RJ Bax in murine thymus is a soluble monomeric protein that displays “9353416 differential detergent-induced conformations. J Biol Chem 273: 1077710783. 26. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, et al. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol 20: 71467159. 27. Gotoh T, Terada K, Oyadomari S, Mori M hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ 11: 390402. 28. Mosser DD, Caron AW, Bourget L, Denis-Larose C, Massie B Role of the human heat shock protein “2987731 hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17: 53175327. 29. Bettaieb A, Averill-Bates DA Thermotolerance in