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J An Overview of Insecticide Resistance. Science 298: 9697. Oyarzu MP, Quiroz A, Birkett MA Insecticide resistance in the horn fly: n alternative control strategies. Med Vet Entomol 22: 188202. STA 4783 Acevedo G, Zapater M, Toloza A Insecticide resistance of house fly, Musca domestica from Argentina. Parasitol Res 105: 489493. Schafer WR Genetic analysis of nicotinic signaling in worms and flies. Journal of Neurobiol 53: 535541. Vardy E, Arkin IT, Gottschalk KE, Kaback HR, Schuldiner S Structural conservation in the major facilitator superfamily as revealed by comparative modeling. Protein Science 13: 18321840. Eiden LE The Cholinergic Gene Locus. Journal of Neurochemistry 70: 22272240. Kaufman PE, Nunez SC, Mann RS, Geden CJ, Scharf M Nicotinoid and pyrethroid insecticide resistance in houseflies collected from Florida dairies. Pest Manag Sci 66: 290294. Millar N, Denholm I Nicotinic acetylcholine receptors: targets for commercially important insecticides. Invert Neurosci 7: 5366. Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, et al. Design and biological activities of L-163,191: a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci U S A 92: 70017005. Bondensgaard K, Ankersen M, Thogersen H, Hansen BS, Wulff BS, et al. Recognition of Privileged Structures by G-Protein Coupled Receptors. J Med Chem 47: 888899. Hughes DJ, Worthington PA, Russel CA, Clarke ED, Peace JE, et al. Spiroindolinepiperidine Derivatives. WO/2003/ 106457. Cheng Y, Chapman KT ” Solid phase synthesis of spiroindoline. Tet Lett 38: 14971500. Maligres PE, Houpis I, Rossen K, Molina A, Sager J, et al. Synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677. Tetrahedron 53: 1098310992. Cassayre J, Molleyres L-P, Maienfisch P, Cederbaum F Spiroindoline Derivatives Having Insecticidal Properties. WO/2005/ 058897. 18. Jeschke P The unique role of halogen substituents in the design of modern agrochemicals. Pest Manag Sci 66: 1027. 19. Thompson GD, Dutton R, Sparks TC Spinosad a case study: an example from a natural products discovery programme. Pest Manag Sci 56: 696702. 20. Rand 11118042” JB, Russell RL Choline acetyltransferase-deficient mutants of the nematode caenorhabditis elegans. Genetics 106: 227248. 21. Nguyen M, Alfonso A, Johnson CD, Rand JB Caenorhabditis elegans Mutants Resistant to Inhibitors of Acetylcholinesterase. Genetics 140: 527535. 22. Alfonso A, Grundahl K, Duerr JS, Han HP, Rand JB The Caenorhabditis elegans unc-17 gene: a putative vesicular acetylcholine transporter. Science 261: 617619. 23. Rand JB Genetic Analysis of the cha-1-unc-17 Gene Complex in Caenorhabditis. Genetics 122: 7380. 24. Brand AH, Perrimon N Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401415. 25. Clarkson ED, Rogers GA, Parsons SM Binding and active transport of large analogues of acetylcholine by cholinergic synaptic vesicles in vitro. J Neurochem 59: 695700. 26. Henry J-P, Scherman D Radioligands of the vesicular monoamine transporter and their use as markers of monoamine storage vesicles. Biochem Pharmacol 38: 23952404. 27. Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, et al. Predicting new molecular targets for known drugs. Nature 462: 175181. 28. Fliri AF, Loging WT, Thadeio PF, Volkmann RA Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A 102: 261266. 29. Evans BE, Rittle KE, Bock MG, DiPardo RM, Frei

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