Anti-CTSC (376-390) antibody produced in rabbit

Product Name: Anti-CTSC (376-390) antibody produced in rabbit

Synonym: Anti-CPPI; Anti-DPP1; Anti-DPPI; Anti-Dipeptidyl-peptidase 1 precursor; Anti-HMS; Anti-JP; Anti-JPD; Anti-PALS; Anti-PLS

Product Type: Chemical

CAS NO: 132-69-4ATP Synthase inhibitors
antibody Form: IgG fraction of antiserum
application(s)
western blot: 1:500-1:2,000
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: antigen mol wt ~52 kDa
Shipped in: dry ice
species reactivity
human
Storage temp.: −20°C
Application: Anti-CTSC (376-390) antibody is suitable for western blot analysis at a dilution of 1:500-1:2000.

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions:
CTSC (Cathepsin C), a lysosomal cysteine proteinase, belongs to the papain superfamily. It act as mediators of programmed cell death/apoptosis. Apoptosis pathways is dependent on lysosomal cathepsin activity. It plays a key role in protein degradation and proenzyme activation. It is synthesized as pre-proenzymes. Furthermore, they are post-translationally glycosylated and phosphorylated to active enzymes. Defects in CTSC in human causes Papillon-Lefevre syndrome, an autosomal recessive disorder.
Immunogen:
synthetic peptide corresponding to amino acids 376-390 of human CTSC
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/91/4/370