Product Name: Anti-E2F1 antibody produced in rabbit
Synonym: Anti-E2F transcription factor 1
Product Type: Chemical
CAS NO: 1011301-27-1CFTR inhibitors
antibody Form: IgG fraction of antiserum
application(s)
immunohistochemistry: suitable
western blot: suitable
clone
polyclonal
Concentration: 0.5 mg – 1 mg/mL
Form: buffered aqueous solution
Mol wt: mol wt 47 kDa
NCBI accession no.
NP_005216
Shipped in: wet ice
species reactivity
human
Storage temp.: −20°C
Application: Rabbit polyclonal anti-E2F1 antibody is used to tag E2F transcription factor 1 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of E2F transcription factor-1 in cell proliferation, apoptosis and tissue homeostasis.
General description: E2F transcription factor 1 (E2F1), a member of the E2F family of transcription factors, is involved in the regulation of the cell cycle. E2F1 mediates cell proliferation and p53-dependent and independent apoptosis. E2F1 binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. The Rb/E2F1 axis exerts essential functions such as maintaining epidermal homoeostasis and suppressing tumour development in tissues such as the epidermis.
Immunogen:
The immunogen for anti-E2F1 antibody: synthetic peptide derected towards the middle region of human E2F1
Physical Form: Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Sequence:
Synthetic peptide located within the following region: LCPEETVGGISPGKTPSQEVTSEEE
Specificity:
Rabbit polyclonal anti-E2F1 antibody reacts with human E2F transcription factor 1.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/328/2/621