Product Name: Anti-MyC antibody produced in rabbit
Synonym: Anti-Myc protein
Product Type: Chemical
CAS NO: 88-04-0IFNAR inhibitors
antibody Form: IgG fraction of antiserum
application(s)
immunohistochemistry: suitable
western blot: suitable
biological source
rabbit
clone
polyclonal
Concentration: 0.5 mg – 1 mg/mL
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: mol wt 19 kDa
NCBI accession no.
NP_002458
Shipped in: wet ice
species reactivity
canine, human, rabbit, pig, guinea pig, horse, mouse, rabbit, rat, sheep
Storage temp.: −20°C
Application: Anti-MyC polyclonal antibody is used to tag Myc protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of Myc in cell cycle progression, apoptosis and cellular transFormation.
General description: Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transFormation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoForms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt′s lymphomas, suggesting its importance in the normal function of this gene.
Immunogen:
The immunogen for anti-MYC antibody: synthetic peptide derected towards the N terminal of human MYC
Physical Form: Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Sequence:
Synthetic peptide located within the following region: MDFFRVVENQQPPATMPLNVSFTNR
Specificity:
Anti-MyC polyclonal antibody reacts with canine, rabbit, pig, human, mouse, and rat Myc proteins.
RIDADR: NONH for all modes of transport
WGK Germany: 2
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/340/1/2