Product Name: Anti-PCBP4 (256-270) antibody produced in rabbit
Synonym: Anti-LIP4; Anti-MCG10; Anti-PCBP4 poly(rC) binding protein 4
Product Type: Chemical
CAS NO: 1884712-47-3VDAC inhibitors
antibody Form: IgG fraction of antiserum
application(s)
western blot: 1:500-1:2,000
biological source
rabbit
clone
polyclonal
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: antigen mol wt ~41 kDa
Shipped in: dry ice
species reactivity
human
Storage temp.: −20°C
Application: Anti-PCBP4 (256-270) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions:
αCP-4 is an RNA-binding protein coded by PCBP4 gene in humans and is mapped to 3p21 containing 10 exons. Induction of this gene expression reduced cell growth, may acts as an tumor suppressor and is associated with RNA-binding protein with lung carcinogenesis. Lack of alpha CP-4 expression is associated with highly proliferative lung tumors and correlates with αCP-4 allele losses. The protein contain two domains homologous to the heterogeneous nuclear ribonucleo-protein K homology (KH) domain. PCBP4 is a novel cellular p53 target gene and is a potential mediator of p53 tumor suppression.
Immunogen:
synthetic peptide corresponding to amino acids 256-270 of human PCBP4
Physical Form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
RIDADR: NONH for all modes of transport
WGK Germany: 2
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/70/4/450