Product Name: Anti-RNF146 antibody produced in rabbit
Synonym: Anti-DKFZP434O1427; Anti-RP3-351K20.1; Anti-Ring finger protein 146; Anti-dJ351K20.1
Product Type: Chemical
CAS NO: 106516-24-9Haspin Kinase inhibitors
antibody Form: IgG fraction of antiserum
application(s)
western blot: suitable
biological source
rabbit
clone
polyclonal
Concentration: 0.5 mg – 1 mg/mL
Conjugate: unconjugated
Form: buffered aqueous solution
Mol wt: mol wt 39 kDa
NCBI accession no.
NP_112225
Shipped in: wet ice
species reactivity
human, horse, mouse, guinea pig
Storage temp.: −20°C
Application: Anti-RNF146 polyclonal antibody is used to tag ring finger protein 146 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles ring finger protein 146 in Wnt signaling and neuroprotection.
Features and Benefits:
Antibody Bioguarantee
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General description: Ring finger protein 146 (RNF146, Iduna) is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase which ubiquitinates proteins for degradation by proteosomes. RNF146 is neuroprotective due to its inhibition of Parthanatos via binding with Poly(ADP-ribose) (PAR). RNF146 regulates Wnt signaling via ubiquitylation of auto-PARsylated tankyrase.
Immunogen:
The immunogen for anti-RNF146 antibody: synthetic peptide derected towards the C terminal of human RNF146
Physical Form: Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Sequence:
Synthetic peptide located within the following region: AVVAQHSLTQQRLLVSNANQTVPDR
Specificity:
Anti-RNF146 polyclonal antibody reacts with human and mouse ring finger protein 146 proteins.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/351/1/54