BF-170 hydrochloride

Product Name: BF-170 hydrochloride

Synonym: 2-(4-aminophenyl)quinoline hydrochloride; NSC 168387 hydrochloride

CAS Number: 22191-97-5
Empirical Formula (Hill Notation): C₁₅H₁₂N₂ · HCl
Molecular Weight: 256.73
MDL Number: MFCD08705340
Linear Formula: C₁₅H₁₂N₂ · HCl
Product Type: Chemical

CAS NO: 1207456-01-6APC inhibitors
Assay: ≥98% (HPLC)
color
orange
Form: solid
InChI Key
UYYPMQOFLJHJAW-UHFFFAOYSA-N
solubility
H2O: soluble10 mg/mL
Storage condition: desiccated

protect from light

under inert gas
Storage temp.: −20°C
Biochem/physiol Actions:
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.
Caution:
Product is air sensitive, store under inert gas.
Features and Benefits:
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
Legal InFormation: LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Symbol
GHS05, GHS07
Signal word
Danger
Hazard statements
H302-H315-H318-H335
Precautionary statements
P261-P280-P305 + P351 + P338
Hazard Codes
Xn
Risk Statements
22-37/38-41
Safety Statements
26
RIDADR: NONH for all modes of transport
WGK Germany: 3
Purity: ≥98% (HPLC)
Storage Temp.: −20°C
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/56/4/446