BRD7389

Product Name: BRD7389

Synonym: 1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione; 1-[(2-Phenylethyl)amino]–naphtho-3H-[1,2,3-de]quinoline-2,7-dione

CAS Number: 376382-11-5
Empirical Formula (Hill Notation): C₂₄H₁₈N₂O₂
Molecular Weight: 366.41
Linear Formula: C₂₄H₁₈N₂O₂
Product Type: Chemical

CAS NO: 847591-62-2Aromatase inhibitors
Assay: ≥98% (HPLC)
color
orange
Form: powder
solubility
DMSO: >20 mg/mL
Storage temp.: 2-8°C
Biochem/physiol Actions:
BRD7398 is a RSK kinase inhibitor that induces insulin expression and differentiation of pancreatic alpha into beta cells. BRD7398 inhibits RSK1, RSK2 and RSK3; IC50 values of 1.5, 2.4 and 1.2 uM, respectively. Treatment of mouse aTC1 cells with BRD7398 induced expression of b-cell markers Pdx1, Pax4, Iapp and Npy and also induced insulin production.
Features and Benefits:
This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Purity: ≥98% (HPLC)
Storage Temp.: 2-8°C
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/60/1/1