Cetirizine dihydrochloride

Product Name: Cetirizine dihydrochloride

Synonym: [2-[4-[(4-Chlorophenyl)phenylmethyl]–1-piperazinyl]ethoxy]acetic acid dihydrochloride

CAS Number: 83881-52-1
Empirical Formula (Hill Notation): C₂₁H₂₅ClN₂O₃ · 2HCl
Molecular Weight: 461.81
MDL Number: MFCD00941428
Linear Formula: C₂₁H₂₅ClN₂O₃ · 2HCl
Product Type: Chemical

CAS NO: 543906-09-8CRTH2 (GPR44) inhibitors
Assay: ≥98% (HPLC)
color
white to beige
Form: powder
InChI Key
PGLIUCLTXOYQMV-UHFFFAOYSA-N
originator
Pfizer
relevant disease(s)
allergies
solubility
H2O: soluble5 mg/mL, clear
Biochem/physiol Actions:
Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer.
Features and Benefits:
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Features and Benefits:
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
Features and Benefits:
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Features and Benefits:
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal InFormation: LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Symbol
GHS07
Signal word
Warning
Hazard statements
H302
Hazard Codes
Xn
Risk Statements
22
RIDADR: NONH for all modes of transport
WGK Germany: 3
RTECS
AG0980000
Purity: ≥98% (HPLC)
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/79/3/250