Ciproxifan hydrochloride

Product Name: Ciproxifan hydrochloride

Synonym: Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]–methanone hydrochloride

CAS Number: 1049741-81-2
Empirical Formula (Hill Notation): C₁₆H₁₈N₂O₂ · HCl
Molecular Weight: 306.79
MDL Number: MFCD08705321
Linear Formula: C₁₆H₁₈N₂O₂ · HCl
Product Type: Chemical

CAS NO: 486-62-4ATP Synthase inhibitors
Assay: ≥98% (HPLC)
color
off-white
Form: solid
InChI Key
PWAPSKMHZQQTRJ-UHFFFAOYSA-N
solubility
DMSO: soluble30 mg/mL

water, high purity: soluble30 mg/mL
Storage condition: desiccated

under inert gas
Storage temp.: 2-8°C
Biochem/physiol Actions:
Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
Features and Benefits:
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Symbol
GHS07
Signal word
Warning
Hazard statements
H302
Hazard Codes
Xn
Risk Statements
22
RIDADR: NONH for all modes of transport
WGK Germany: 3
Purity: ≥98% (HPLC)
Storage Temp.: 2-8°C
UNSPSC
12352200
PubMed ID:http://jpet.aspetjournals.org/content/88/3/260