Product Name: Monoclonal Anti-Bad antibody produced in rat

MDL Number: MFCD01633042
Product Type: Chemical

CAS NO: 163521-12-8Neprilysin inhibitors
antibody Form: purified immunoglobulin
application(s)
microarray: suitable

western blot: 1 μg/mL using extracts from mouse CTLL2 or L929 cells.
biological source
rat
clone
64103, monoclonal
Conjugate: unconjugated
Form: lyophilized powder
isotype
IgG2a
species reactivity
mouse
Storage temp.: −20°C
Application: Monoclonal Anti-Bad antibody produced in rat is suitable for western blotting at a concentration of 1μg/mL by using mouse CTLL2 or L929 cell extract. It is also suitable for microarray.
Biochem/physiol Actions:
The protein encoded by this gene Forms heterodimers with BCL-xL and BCL-2 and replaces Bax, which in turn inverts the death repressor activity of Bcl-xL and positively regulates cell apoptosis. Bad is phosphorylated on two serine residues embedded in canonical 14-3-3 binding sites in response to IL-3, a survival factor.Phosphorylated Bad does not bind Bcl-XL and is sequestered in the cytosol bound to 14-3-3, a specific phosphoserine-binding protein. The growth factors that promote cell survival activate the threonine kinase Akt, which phosphorylates Bad causing suppression of apoptosis.
General description: Bad (Bcl-2-antagonist of cell death), initially identified by its interaction with Bcl-2 and Bcl-XL, is a distant Bcl-2 family member. Bad bears only the most universally conserved amino acids within BH1 and BH2 domains, and lacks the typical hydrophobic C-terminal signal anchor.
Immunogen:
purified N-terminal portion of recombinant mouse Bad
Physical Form: Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, pH 7.4 with 5% trehalose.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/50/2/165

Product Name: Monoclonal Anti-Bad antibody produced in rat

MDL Number: MFCD01633042
Product Type: Chemical

CAS NO: 163521-12-8Neprilysin inhibitors
antibody Form: purified immunoglobulin
application(s)
microarray: suitable

western blot: 1 μg/mL using extracts from mouse CTLL2 or L929 cells.
biological source
rat
clone
64103, monoclonal
Conjugate: unconjugated
Form: lyophilized powder
isotype
IgG2a
species reactivity
mouse
Storage temp.: −20°C
Application: Monoclonal Anti-Bad antibody produced in rat is suitable for western blotting at a concentration of 1μg/mL by using mouse CTLL2 or L929 cell extract. It is also suitable for microarray.
Biochem/physiol Actions:
The protein encoded by this gene Forms heterodimers with BCL-xL and BCL-2 and replaces Bax, which in turn inverts the death repressor activity of Bcl-xL and positively regulates cell apoptosis. Bad is phosphorylated on two serine residues embedded in canonical 14-3-3 binding sites in response to IL-3, a survival factor.Phosphorylated Bad does not bind Bcl-XL and is sequestered in the cytosol bound to 14-3-3, a specific phosphoserine-binding protein. The growth factors that promote cell survival activate the threonine kinase Akt, which phosphorylates Bad causing suppression of apoptosis.
General description: Bad (Bcl-2-antagonist of cell death), initially identified by its interaction with Bcl-2 and Bcl-XL, is a distant Bcl-2 family member. Bad bears only the most universally conserved amino acids within BH1 and BH2 domains, and lacks the typical hydrophobic C-terminal signal anchor.
Immunogen:
purified N-terminal portion of recombinant mouse Bad
Physical Form: Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, pH 7.4 with 5% trehalose.
RIDADR: NONH for all modes of transport
WGK Germany: 3
Storage Temp.: −20°C
UNSPSC
12352203
PubMed ID:http://jpet.aspetjournals.org/content/50/2/165