hibition of H3K27 demethylation activates the demethylase-independent function of Utx Taken together, our data indicate that Utx directly regulates the expression of Prdm14 and Tsix in a demethylase-dependent manner, and suggest that Utx controls Xist via demethylase-independent mechanisms. Ascorbic acid enhances the demethylase activity of Utx and induces its target genes L-ascorbic acid /Vitamin C …
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