D South America, Europe, the Middle East, Asia and Africa. Trial Registration: ClinicalTrials.gov NCT01506492 four January 2012. Keywords: Sophisticated PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21296415 cancer, Psychotherapy, Randomized controlled trial Correspondence: gary.rodinuhn.ca 1 Department of Supportive Care, Princess Margaret Cancer Centre, University Overall health Network, 16th Floor, 610 University Avenue, Toronto, ON M5G 2M9, Canada 2 Department of Psychiatry, University of Toronto, 8th Floor, 250 College Street, Toronto, ON M5T 1R8, Canada Full list of author information is offered at the finish in the article2015 Lo et al. Open Access This article is distributed under the terms on the Creative Commons Attribution 4.0 International License (http:creativecommons.orglicensesby4.0), which permits unrestricted use, distribution, and reproduction in any medium, supplied you give proper credit to the original author(s) and also the source, present a link for the Inventive Commons license, and indicate if modifications have been made. The Inventive Commons Public Domain Dedication waiver (http:creativecommons.orgpublicdomainzero1.0) applies to the information made accessible in this write-up, unless otherwise stated.Lo et al. Trials (2015) 16:Page two ofBackground Advanced or metastatic cancer is predictably linked with challenges and burdens that may perhaps cause symptoms of depression and demoralization and fears of suffering, dependency, and mortality [1]. The multiple physical symptoms, the dramatic alteration in support wants and in private relationships, the difficulty navigating a complicated health care system, and the threat of impending mortality all may possibly constitute pathways to distress within this population [2]. The challenge for people within this circumstance is to sustain a “Apigenine double awareness” that makes it possible for them to stay engaged in life although facing 
the imminence of physical deterioration, shortened survival, and death [3]. Various person and social variables may possibly shield individuals in this circumstance, but experienced support may also be of value to stop and treat the distress that frequently emerges in this population [4]. Clinically important depressive symptoms might be frequent in patients with sophisticated cancer and can be understood as a final frequent pathway of distress, emerging in response for the interaction of several disease-related, individual and psychosocial components [1, two, 5]. Probably the most prominent of those would be the physical burden of disease, attachment insecurity (i.e., be concerned about the availability of supportive relationships and the capacity to create use of them for emotional support), reduced self-esteem, feelings of hopelessness and impaired spiritual well-being [1, 2]. Even though several psychotherapeutic modalities have already been employed to treat depression (e.g., cognitive behavior therapy and interpersonal therapy), optimistic outcomes and sustained improvement could be probably when remedy is directed at etiological and pathogenic elements which might be specific for the context in which disturbances arise [8]. Preliminary findings in sufferers with advanced cancer also suggest that psychological treatment options for depression are preferred over pharmacological ones [9], and that person psychotherapy is preferred over group therapy due to the fact sessions could be flexibly tailored to patients’ person needs, taking into account other clinic appointments and fluctuations in wellness status [103]. To address the relative lack of evidence-based individual therapies tailored for this population, we have developed a novel.