Olumn shows the ratio of overlapping module genes with the gene set (Overlap), the following 4 columns are connected to statistics (P-value, Adjusted P-value, Z-score, Combined Score) plus the fifth column shows the symbols on the overlapping genes. The gene sets are ranked by combined score. (XLSX 431 kb) Added file 18: ModuleAnnotation_enrichR_M16. Annotation Angiopoietin-related protein 4/ANGPTL4 Protein HEK 293 outcome of M16 performed in enrichR. EnrichR currently contains annotated gene sets from 102 gene set libraries organized in 8 categories. Details on the gene set libraries in EnrichrR is often identified in publications [25, 56]. Every tab of the file contains gene sets of a specific library that was found to be enriched within the module. The very first column represent the gene set (Term), the second column shows the ratio of overlapping module genes together with the gene set (Overlap), the following four columns are connected to statistics (P-value, Adjusted P-value, Z-score, Combined Score) along with the fifth column shows the symbols from the overlapping genes. The gene sets are ranked by combined score. (XLSX 125 kb) Added file 19: ModuleAnnotation_enrichR_M17. Annotation outcome of M17 performed in enrichR. EnrichR currently includes annotated gene sets from 102 gene set libraries organized in 8 categories. Facts of your gene set libraries in EnrichrR could be located in publications [25, 56]. Each tab of the file consists of gene sets of a specific library that was located to be enriched inside the module. The very first column represent the gene set (Term), the second column shows the ratio of overlapping module genes using the gene set (Overlap), the following 4 columns are related to statistics (P-value, Adjusted P-value, Z-score, Combined Score) and also the fifth column shows the symbols with the overlapping genes. The gene sets are ranked by combined score. (XLSX 412 kb) Further file 20: ModuleAnnotation_enrichR_M18. Annotation outcome of M18 performed in enrichR. EnrichR currently contains annotated genesets from 102 gene set libraries organized in eight categories. Information from the gene set libraries in EnrichrR might be located in publications [25, 56]. Every single tab with the file contains gene sets of a specific library that was identified to be enriched within the module. The first column represent the gene set (Term), the second column shows the ratio of overlapping module genes with the gene set (Overlap), the following four columns are connected to statistics (P-value, Adjusted P-value, Z-score, Combined Score) and the fifth column shows the symbols of the overlapping genes. The gene sets are ranked by combined score. (XLSX 72 kb)Abbreviations ASO: Overexpressed wild-type human -synuclein; BDNF: Brain erived neurotrophic aspect; BT: Beam Transversal; DLB: Dementia with Lewy Body; GLT-1: Glutamate sort I transporter; NO: Novel Object; NP: Novel Location; NSCs: Neural stem cells; WGCNA: Weighted co-expression network evaluation Acknowledgments We gratefully acknowledge Dr. Eliezer Masliah for development of the IL-1 beta Protein E. coli original PDGF- line-D ASO model and delivering colony founder mice. We also thank Jacqueline Caesar M.S. for assistance in RNA isolation and purification and also the UCI Genomics High-Throughput Facility and specially Dr. Melanie Oakes for their assistance and useful discussion. We also express our gratitude for UCI HPC help and specially Dr. Harry Mangalam and Garr Updegraff for their generous support, as well as the UCI Research Computing group especially Allen Schiano and Dana Roode. This perform was supported by an NSF Fellowship.