Dulus and toughness with the PEG-SH/PEG-Mal/Pep hydrogels. Figure S
Dulus and toughness with the PEG-SH/PEG-Mal/Pep hydrogels. Figure S8: Normalized maximum anxiety for unique hydrogels in 100 compression-relaxation cycles. Figure S9: Swelling ratios and porosities of various hydrogels. Figure S10: SEM photos of distinctive PEG-SH/PEG-Mal/Pep hydrogels. Figure S11: SEM images of PEG-SH/PEG-Mal/FKG hydrogels at diverse FKG:PEG-Mal ratios. Figure S12: Removing of the FKG peptide inside the hydrogels by the dialysis. Figure S13: Cell Fmoc-Gly-Gly-OH ADC Linkers culture and viability of HAMSC cells around the PEG-SH/PEG-Mal/Pep hydrogels after incubation for 24 h. Figure S14: Cell culture and viability of HuH-7 cells on the PEG-SH/PEG-Mal/Pep hydrogels just after incubation for 60 h. Figure S15: Determination in the reaction kinetics of PEG-SH and PEG-Mal. Figure S16: Summary of reaction and gelation prices on the 4-armed PEG-Mal and 4-armed PEG-SH. Author Contributions: Conceptualization, Y.C. (Yi Cao), Y.J. (Yonghua Jiao), and B.X.; Methodology, B.X.; Application, B.X.; Validation, Y.C. (Yi Cao), Y.J. (Yonghua Jiao), and B.X.; Formal evaluation, B.X., T.M., and Y.C. (Yi Cao); Investigation, Y.G., Y.J. (Yuxin Jiang), Y.Z., Z.Z., and Z.J.; Resources, Y.G. and J.G.;Gels 2021, 7,11 ofData curation, Y.G. and J.G.; Writing–original draft preparation, Y.G., J.G., and B.X.; Writing–review and editing, Y.C. (Yuanqi Cheng), Y.J. (Yonghua Jiao), and B.X.; Visualization, B.X.; Supervision, Y.C. (Yi Cao), Y.J. (Yonghua Jiao), and B.X.; Project administration, Y.C. (Yi Cao); Funding acquisition, Y.C. (Yi Cao), Y.J. (Yonghua Jiao), and B.X. All authors have study and agreed for the published version of the manuscript. Funding: This investigation was funded by the National Key R D Plan of China (Grant No.2020YFA 0908100), the National Organic Science Foundation of China (No. 11934008, 11804148, 11674153 and 12002149), the Basic Investigation Funds for the Central Universities (No. 020414380187), and the Technological Innovation Foundation of Nanjing University (020414913413). Information Availability Statement: All data are available in the key text or the Supplementary Information and facts. Conflicts of Interest: The authors declare no conflict of interest.
G C A T T A C G G C A TgenesCase ReportWDR36-Associated Neurodegeneration: A Case Report Highlights Feasible Mechanisms of Regular Tension GlaucomaElana Meer 1 , Tomas S. Aleman 1,2 and Ahmara G. Ross 1,two, Division of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA; [email protected] (E.M.); [email protected] (T.S.A.) FM Kirby Center for Molecular Ophthalmology, Olesoxime Protocol Scheie Eye Institute, University of Pennsylvania Perelman College of Medicine, Philadelphia, PA 19104, USA Correspondence: [email protected]: Meer, E.; Aleman, T.S.; Ross, A.G. WDR36-Associated Neurodegeneration: A Case Report Highlights Attainable Mechanisms of Standard Tension Glaucoma. Genes 2021, 12, 1624. https://doi.org/ 10.3390/genes12101624 Academic Editor: Susan M. Downes Received: two September 2021 Accepted: 12 October 2021 Published: 15 OctoberAbstract: WDR36 is a single of a number of genes implicated within the pathogenesis of adult-onset major open angle glaucoma (POAG). Right here we describe in detail the phenotype of a patient with pathogenic variation in WDR36 who presented using a protracted history of central vision loss. On exam visual acuities have been at 20/100 level, had a tritan colour defect and showed central arcuate visual field defects on visual field testing. Enlarged cup-to-disk ratio.