Nancies. Cancer 112, 274sirtuininhibitor83, doi:10.1002/cncr.23159 (2008). 15. Ito, T. et al. Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan. J Gastroenterol 45, 234sirtuininhibitor43, doi:ten.1007/s00535-009-0194-8 (2010). 16. Oberg, K. Eriksson, B. Endocrine tumours on the pancreas. Most effective Pract Res Clin Gastroenterol 19, 753sirtuininhibitor81, doi:10.1016/j. bpg.2005.06.002 (2005). 17. Jonkers, Y. M., Ramaekers, F. C. Speel, E. J. Molecular alterations in the course of insulinoma tumorigenesis. Biochim Biophys Acta 1775, 313sirtuininhibitor32, doi:ten.1016/j.bbcan.2007.05.004 (2007). 18. Bertolino, P. et al. Pancreatic beta-cell-specific ablation from the various endocrine neoplasia sort 1 (MEN1) gene causes complete penetrance of insulinoma improvement in mice. Cancer Res 63, 4836sirtuininhibitor841 (2003). 19. Jiang, W. J. et al. Frequent loss of heterozygosity at MEN-1 gene and chromosome 22q in insulinomas and its significance. Zhonghua Yi Xue Za Zhi 84, 1705sirtuininhibitor709 (2004). 20. Cupisti, K. et al. Lack of MEN1 gene mutations in 27 sporadic insulinomas. Eur J Clin Invest 30, 325sirtuininhibitor29, doi:ten.1046/j.13652362.2000.00620.x (2000). 21. Cao, Y. et al. Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1. Nat Commun four, 2810, doi:10.1038/ ncomms3810 (2013). 22. Roldo, C. et al. MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are connected with distinctive pathologic functions and clinical behavior. Journal of clinical oncology: official journal on the American Society of Clinical Oncology 24, 4677sirtuininhibitor684, doi:10.Hemoglobin subunit alpha/HBA1 Protein site 1200/JCO.2005.05.5194 (2006). 23. Missiaglia, E. et al. Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. Journal of clinical oncology: official journal on the American Society of Clinical Oncology 28, 245sirtuininhibitor55, doi:ten.Noggin Protein Purity & Documentation 1200/JCO.2008.21.5988 (2010). 24. Speisky, D. et al. Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau sufferers. Clin Cancer Res 18, 2838sirtuininhibitor849, doi:ten.1158/1078-0432.CCR-11-2759 (2012). 25. Jiang, X. et al. miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulinomas. Endocrinology 156, 2429sirtuininhibitor439, doi:10.1210/en.2014-1966 (2015).
Open AccessProtocolA cluster-randomised controlled trial integrating a community-based water, sanitation and hygiene programme, with mass distribution of albendazole to lessen intestinal parasites in Timor-Leste: the WASH for WORMS study protocolSusana Vaz Nery,1 James S McCarthy,two Rebecca Traub,3 Ross M Andrews,4 Jim Black,5 Darren Gray,1 Edmund Weking,six Jo-An Atkinson,7 Suzy Campbell,1 Naomi Francis,5 Andrew Vallely,eight Gail Williams,9 Archie ClementsTo cite: Nery SV, McCarthy JS, Traub R, et al.PMID:23614016 A cluster-randomised controlled trial integrating a community-based water, sanitation and hygiene programme, with mass distribution of albendazole to cut down intestinal parasites in Timor-Leste: the WASH for WORMS study protocol. BMJ Open 2015;five:e009293. doi:10.1136/bmjopen-2015009293 Prepublication history for this paper is available on-line. To view these files please take a look at the journal on the web (dx.doi.org/10.1136/ bmjopen-2015-009293). Received two July 2015 Revised 25 November 2015 Accepted 27 NovemberABSTRACT Introduction: There is certainly limited proof demonstratingthe advantages of community-based water, sanitation and hygiene (WASH) programmes on infe.