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Dendritic cells (DCs) are skilled antigen presenting cells (APCs) and crucial modulators of T- and B-cell immunity mostly owing to their superior ability to take up and present antigens [1,2].Calcein Biological Activity Diverse subsets of DCs show variations in the abilities and modes of antigen-presentation.Nitrosoglutathione Epigenetics CD8a+ conventional DCs (cDCs), a minor population among total mouse spleen DCs, have the selective ability to cross-present exogenous antigens to induce cytotoxic T cell (CTL) activation [3].PMID:24578169 In contrast, the extracellular antigens are captured and moved to endosome/ lysosome in CD8a2 cDCs and, degraded to antigenic peptides, that are complexed with MHC class II molecules and recognized by CD4 T cells [6]. DCs may also straight sense pathogen elements by pattern recognition receptors (PRRs), for instance toll like receptors (TLRs), scavenger receptors (SRs), Ctype lectins, mannose receptors and complement receptors [7]. The activation of those receptors induces signal events that regulate the expression of pro-inflammatory and immune mediators [7]. Tumor vaccines seek to induce CTL responses against tumors [2]. To achieve effective tumor cell killing, distinct tactics have been evaluated for inducing T cell responses against tumor antigens [2.