The disappearance of NAGFTPQER would readily be detected, and the huge peptide would very likely be determined, revealing the identity of this variant
The Gly241Arg variant was discovered by the absence of the wild type tryptic peptide QGFGELLQAVPLADSFR and the appearance of the pSB-431542eptides QGFR and ELLQAVPLADSFR that resulted from tryptic cleavage of…